The Shwartzman Phenomenon. I. Inhibitory Action of Nitrogen Mustard (HN2)

Abstract

The inhibitory action of HN2 in the Shwartzman phenomenon is confirmed, but evidence is presented that the HN2 acts systemically rather than locally on the endo-thelium of the preparatory site, since protection of the preparatory site from the action of the HN2 by means of a skin clamp, fails to influence the inhibition, while occlusion of the aorta with protection of the lower limbs decreases or prevents the inhibitory action.