Peptide synthesis. Part 13. Feedback control in solid phase synthesis. Use of fluorenylmethoxycarbonyl amino acid 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl esters in a fully automated system
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2895-2901
- https://doi.org/10.1039/p19880002895
Abstract
A spectrometric technique is described for monitoring the course of acylation reactions by the title esters in solid phase peptide synthesis. The procedure has allowed construction of a fully automated peptide synthesizing system in which acylation and deprotection steps may be checked automatically for completion before proceeding to the next amino acid residue.Keywords
This publication has 2 references indexed in Scilit:
- Peptide synthesis. Part 2. Procedures for solid-phase synthesis using Nα-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65–74 decapeptideJournal of the Chemical Society, Perkin Transactions 1, 1981
- Peptide synthesis. Part 1. Preparation and use of polar supports based on poly(dimethylacrylamide)Journal of the Chemical Society, Perkin Transactions 1, 1981