THE THYMOLYTIC ACTIVITIES OF 16α, 17α KETALS OF TRIAMCINOLONE1

Abstract

The relative thymolytic activities of triamcinolone acetonide and several of its homologous ketonide variants were assessed in a 48-hour bioassay employing intact immature female rats. One of the alkyl substituents of the ketonide moiety was varied in a regular way from methyl through hexyl while the other was held at methyl throughout the homologous series. The methyl, ethyl, propyl, butyl, pentyl, and hexyl analogs were more active than hydrocortisone; however, the latter two were less efficacious than triamcinolone.