Inhibition of ?-aminobutyric acid release from rat cerebral cortex slices by barbiturate anesthesia

Abstract
Amobarbital and pentobarbital anesthesia inhibited the potassium-stimulated, Ca-dependent release of γ-aminobutyric acid (GABA) from rat cerebral cortex slices during incubation in vitro. Inhibition of GABA release was not found when slices were prepared from rats shortly after they awakened from amobarbital anesthesia. Phenobarbital anesthesia did not affect the release of GABA.