Meiosis of trisomy 21 in the human pachytene oocyte
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Chromosoma
- Vol. 57 (2), 155-163
- https://doi.org/10.1007/bf00292913
Abstract
Association modalities of the three 21 chromosomes were studied during pachytene in three trisomy 21 fetuses whose chromosomal constitution was identified following amniocentesis. — Three classes of images were observed: a trivalent, a trivalent presenting an important asynaptic region of the long arm, and a bivalent accompanied by a univalent. Such behaviour is analagous to that observed in all trisomic organisms. — We have been able to establish the sequence of chromomeres, whose number varies from 9 to 14 according to the state of contraction in the 21 chromosome. Each band is thus subdivided into several sub-bands: at maximal elongation 2 sub-bands for band p11, 4 for q21 and 3 for q222. In addition, the interchromomeric clear bands q221 and q223 are also subdivided by the presence of a very small chromomere. In this way, the G-bands visible on mitotic metaphase chromosomes result from the compression together of several chromomeres whose individuality disappears as chromosomal condensation increases with progression of prophase.Keywords
This publication has 14 references indexed in Scilit:
- Chiasma distribution at diakinesis in the normal human maleHereditas, 2009
- Mechanisms of chromosome banding: VI. Whole mount electron microscopy of banded metaphase chromosomes and a comparison with pachytene chromosomesExperimental Cell Research, 1975
- Mapping G-bands on human prophase chromosomesCytogenetic and Genome Research, 1975
- AN AIR-DRYING METHOD FOR FIRST MEIOTIC PROPHASE PREPARATIONS FROM MAMMALIAN OVARIESReproduction, 1974
- Mechanisms of chromosome bandingChromosoma, 1974
- Cytogenetic Aspects of Human Male MeiosisPublished by Springer Nature ,1973
- Nucleoli and chromosomes: Their relationships during the meiotic prophase of the human fetal oocyteHuman Genetics, 1972
- Meiosis and spermatogenesis in G-Trisomic malesPublished by Springer Nature ,1971
- Chromosome structure and function in manCytogenetic and Genome Research, 1971
- Chromosome Structure and Function in Man, III. Pachytene Analysis and Identification of the Supernumerary Chromosome in a Case of Down's Syndrome (Mongolism)Proceedings of the National Academy of Sciences, 1970