Quantitative aspects of chirality. I. Method of dissymmetry function

Abstract
To study molecular features connected with chirality, a procedure for the quantitative estimation of the chirality level of compounds of different classes is needed. A procedure for estimating the molecular asymmetry level relative to mirror‐reflection axes of symmetry, S1, S2, S4 and S6, has been developed. The geometrical mean of these parameters is the disymmetry function (DF). To calculate the DF, the molecule must be fixed in the coordinate system, transferred to the main axes of inertia.