The Effect of Glucose Analogues on the Metabolism of Human Leukemic Cells

Abstract

Certain sugar analogues (2-deoxy-D-glucose and 2-deoxy-D-galactose) were shown to be potent glycolytic inhibitors of human leukocytes, human leukemic cells of different types, and a variety of animal tumor cells. In vivo administration of 2-deoxy-D-glucose markedly inhibited glycolysis in 2 of 4 patients with leukemia studied. The possible usefulness of a technique measuring metabolic changes induced by a drug in vivo was discussed.