Conditioned Avoidance Behavior in Primates During Various Experimental Uremic States

Abstract

Primates were trained on a simple avoidance schedule and observed during three experimental uremic states: (a) continuous urine reinfusion; (b) bilateral ureteral ligation; or (c) bilateral nephrectomy. Performance decrements: occurred under (b) and (c) when plasma urea nitrogen (PUN) concentrations reached 195 mg% ; occurred under (a) with PUN concentration as low as 40 mg% ; but were not directly correlated with plasma potassium or sodium ion concentrations.