Activity of Tetracyclines, Nalidixic Acids, and Nitrofurantoin in Two Experimental Models of Escherichia coli Urinary Tract Disease in Rats

Abstract

Oxytetracycline, α-6-deoxyoxytetracycline, nitrofurantoin, and nalidixic acid were studied in two experimental Escherichia coli models of urinary tract infection in rats, i.e., descending pyelonephritis induced by intravenous injection of the organism after temporary ureter occlusion and ascending pyelonephritis induced by administration of the organism into the bladder followed by manually produced reflux.