EFFECT OF LIN-BENZOADENOSINE AND LIN-BENZOADENOSINE 3'-5'-MONOPHOSPHATE ON CYCLIC AMP-DEPENDENT PROTEIN-KINASE ACTIVITY INVITRO
- 1 January 1978
- journal article
- research article
- Vol. 4 (3), 201-207
Abstract
The fluorescent stretched-out analog of cyclic[c]AMP, namely linear-benzo-cAMP, maximally activates rat brain protein kinase and protein kinase from rabbit skeletal muscle. The corresponding linear-benzoadenosine inhibits kinase activity slightly less than does adenosine. The 2.4 .ANG. and wider versions of cAMP and of adenosine interact with protein kinase in a manner similar to that of the natural compounds.This publication has 3 references indexed in Scilit:
- Nucleic acid related compounds. 26. A "geometry-only" method for determining the anomeric configuration of nucleosides based on the H-1' NMR signal of cyclic .alpha. and .beta. 3',5'-mononucleotidesJournal of the American Chemical Society, 1977
- Defined Dimensional Changes in Enzyme Cofactors: Fluorescent "Stretched-Out" Analogs of Adenine NucleotidesScience, 1977
- Defined dimensional changes in enzyme substrates and cofactors. Synthesis of lin-benzoadenosine and enzymic evaluation of derivatives of the benzopurinesJournal of the American Chemical Society, 1976