THE RIBOFLAVIN AND VITAMIN Bc POTENCY OF TISSUES FROM RATS FED SUCCINYL SULFATHIAZOLE WITH AND WITHOUT LIVER SUPPLEMENTS

Abstract

Rats which received 1% of succinylsulfathiazole in addition to the dextrin basal diet grew at a much slower rate than rats without the drug. The riboflavin content of their liver and muscle tissue was not affected by the ingestion of succinylsulfathiazole but when either 2% or 6% of solubilized liver was fed, the riboflavin values were increased over those observed when 300 [mu]gm. of riboflavin/100 gs. of diet were fed. The Bc potency of the livers from rats which received the succinylsulfathiazole was markedly reduced as compared to the Bc potency of the livers from rats which received the basal diets, and the Bc potency of the livers was increased 5-9-fold by the inclusion of 2 or 6% of solubilized liver in the diet.