Interaction of vasoactive intestinal peptide (VIP) with cholinergic stimulation of glucagon secretion
- 1 March 1982
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 38 (3), 405-406
- https://doi.org/10.1007/bf01949419
Abstract
VIP-containing nerve fibers as well as cholinergic nerve fibers have a ubiquitous distribution in the body and both types of nerves have been demonstrated to innervate the pancreatic islets. The present study shows, in the intact, conscious mouse, that VIP and the cholinergic agonist carbachol stimulate glucagon secretion in a dose-dependent manner. Furthermore VIP and carbachol were found to exert potentiating interactions on glucagon secretion. These results suggest the existence of an interactive neural regulation of glucagon secretion, exerted by acetylcholine and VIP.This publication has 13 references indexed in Scilit:
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