In Vitro Antianaerobic Activity of Ertapenem (MK-0826) Compared to Seven Other Compounds
Open Access
- 1 January 2002
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (1), 220-224
- https://doi.org/10.1128/aac.46.1.220-224.2002
Abstract
Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs at which 50% of the strains are inhibited [MIC 50 s], 0.125 to 0.25 μg/ml; MIC 90 s, 1.0 to 2.0 μg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other β-lactams were similar to those of ertapenem.Keywords
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