THE EFFECT OF LOW OXYGEN TENSION ON TISSUE METABOLISM (RETINA)
Open Access
- 20 May 1943
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 26 (5), 467-472
- https://doi.org/10.1085/jgp.26.5.467
Abstract
Lactic acid production by rat retina in a medium containing phosphate was studied chemically. One half as much lactic acid was found as in a medium containing bicarbonate. In our experience the rate of respiration in a phosphate medium was sensitive to oxygen tension, for it was 38 per cent lower at 10 per cent and 51 per cent lower at 5 per cent oxygen than at 100 per cent oxygen. Previously Laser had reported no decrease in respiration at 5 per cent oxygen in phosphate medium. In phosphate medium, when the oxygen tension was varied, respiration and glycolysis bore a reciprocal relationship to each other. In bicarbonate medium, when the oxygen tension was lowered from 95 per cent to 5 per cent there was no significant change in the respiration, but glycolysis was increased nearly to the anaerobic level. This agrees with the earlier experiment of Laser in bicarbonate medium and adds support to his conclusion that the rate of glycolysis is controlled by oxygen tension rather than by the rate of respiration, under the conditions of the experiment.This publication has 7 references indexed in Scilit:
- THE EFFECT OF OXYGEN TENSION ON THE METABOLISM OF CEREBRAL CORTEX, MEDULLA AND SPINAL CORDJournal of Neurophysiology, 1943
- The pasteur effect in bone marrow, with particular reference to results obtained by different methodsJournal of Cellular and Comparative Physiology, 1942
- A critical analysis of the tissue slice method in manometric experimentsBiochemical Journal, 1942
- The metabolism of lactic and pyruvic acids in normal and tumour tissuesBiochemical Journal, 1939
- A COLLOQUIAL CONSIDERATION OF THE PASTEUR AND NEO-PASTEUR EFFECTSCold Spring Harbor Symposia on Quantitative Biology, 1939
- Tissue metabolism under the influence of carbon monoxideBiochemical Journal, 1937
- Tissue metabolism under the influence of low oxygen tensionBiochemical Journal, 1937