Escherichia coli pleiotropic mutant that reduces amounts of several periplasmic and outer membrane proteins
- 1 October 1979
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 140 (1), 229-239
- https://doi.org/10.1128/jb.140.1.229-239.1979
Abstract
A mutant of E. coli K-12 that is reduced from 6- to 10-fold in the amount of alkaline phosphatase found in the periplasmic space was isolated. The reduced synthesis is not due to effects at the level of transcription regulation of the phoA gene, the structural gene for the enzyme. The mutation (termed perA) responsible for this phenotype results in reduced amounts of possibly 6 or more other periplasmic proteins and at least 3 outer membrane proteins. One of the outer membrane proteins affected is protein Ia. Although other possibilities exist, one explanation for the phenotype of the perA mutation is that it affects the cell''s secretory apparatus.This publication has 51 references indexed in Scilit:
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