Gastric Secretory Response to Head Injury
- 1 August 1970
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 101 (2), 200-204
- https://doi.org/10.1001/archsurg.1970.01340260104016
Abstract
The problem of stress ulcer was studied clinically and in the laboratory. Ten of 19 patients comatose following severe cerebral trauma showed evidence of gastric acid hypersecretion within the first week posttrauma. Three of the ten bled briefly from presumed stress ulcer. Hypersecretion was reduced in three patients after administration of a parasympatholytic drug. Acid hypersecretion occurred both in patients with and without corticosteroid therapy. The "Cushing's ulcer" appears to differ from other forms of stress ulcer in having a higher incidence of associated gastric hyperacidity. Neostigmine bromide, pilocarpine hydrochloride, vitamin A, and phytohemagglutinin failed to stimulate mucus secretion when used topically in gastric pouches. The concept of a topical mucigogue for use in stress ulcer patients remains to be established.Keywords
This publication has 7 references indexed in Scilit:
- SULFATE-CONTAINING GASTRIC MUCUS COMPONENTS AND PEPTIC ULCER: A POSSIBLE RELATIONSHIPJournal of the American Geriatrics Society, 1969
- Gastric Acidity in the Comatose PatientJournal of Neurosurgery, 1969
- REGULATION OF SECRETION OF MUCUS FROM THE GASTRIC ANTRUM*Annals of the New York Academy of Sciences, 1967
- THE EFFECTS OF INTRACRANIAL DISEASE ON GASTRIC SECRETIONBrain, 1960
- Studies on the function of vitamin A in mucopolysaccharide biosynthesisBiochimica et Biophysica Acta, 1960
- Stimulation of Cell-Free Gastric Mucus by the Topical Application of Acetylcholine.Experimental Biology and Medicine, 1951
- PATHOGENESIS OF GASTRODUODENAL ULCERArchives of Surgery, 1942