Fibroblast interferon induces synthesis of four proteins in human fibroblast cells.
- 1 April 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (4), 1824-1827
- https://doi.org/10.1073/pnas.76.4.1824
Abstract
Treatment of human diploid fibroblasts with fibroblast interferon for 8 h inhibited replication of vesicular stomatitis virus. When the total cell protein of cells treated with interferon for 8 h was compared to the total cell protein of untreated cells by 2-dimensional gel electrophoresis, the interferon-treated cells were found to contain 4 proteins not found in untreated cells. Addition of actinomycin D to the cells concurrently with interferon inhibited the synthesis of the 4 proteins. These proteins are apparently induced by interferon and they may be involved in the inhibition of virus replication.Keywords
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