Dual infections of mice: Visceral larva migrans and sublethal infection with Japanese encephalitis virus

Abstract

Experiments in 3 weeks old albino mice with Toxocara canis and sublethal infection with JE virus established a marked synergestic effect in dually infected mice. The results are discussed to indicate the possible rôle of visceral larva migrans in creating explosive outbreaks of “acute encephalopathy syndrome” in individuals having simultaneous infection with a virus (es) which, alone, might produce only mild illness. The nature of the possible mechanisms involved yet remains to be understood.