A diffusable clastogenic factor in ataxia telangiectasia
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 27 (2-3), 155-161
- https://doi.org/10.1159/000131476
Abstract
Cocultivation of plasma and lymphocytes from ataxia telangiectasia (AT) patients with those of normal individuals resulted in a significant increase in chromosomal damage in the normal cells. Tissue culture medium used to cultivate AT skin fibroblasts also significantly increased chromosome breakage in PHA-stimulated normal lymphocytes. This clastogenic effect was maximal when the “conditioned medium” was 8–9 days old. A similar effect was not observed with medium derived from normal skin fibroblasts. These observations suggest the presence of a clastogenic factor in the plasma of AT patients which may also be produced by AT skin fibroblasts in culture.Keywords
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