Heterogeneity in Biological Activity of Human Factor VIII Antibodies
- 1 January 1975
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 29 (1), 99-107
- https://doi.org/10.1111/j.1365-2141.1975.tb01803.x
Abstract
Antibodies against factor VIII collected from six patients were studied for their effect on factor-VIII coagulant activity, Willebrand factor activity (WF) and factor-VIII-related antigen. The results demonstrate differences between individual antibodies; some acting primarily as anti factor VIII, others inhibiting both after VIII and WF. Differences in effect between plasma and serum indicate that the process of coagulation alters the interaction of these antibodies.Keywords
This publication has 16 references indexed in Scilit:
- Von Willebrand Factor: Dissociation from Antihemophilic Factor Procoagulant ActivityScience, 1973
- Quantitative Assay of a Plasma Factor Deficient in von Willebrand's Disease that is Necessary for Platelet Aggregation. RELATIONSHIP TO FACTOR VIII PROCOAGULANT ACTIVITY AND ANTIGEN CONTENTJCI Insight, 1973
- FACTOR VIII COAGULANT ACTIVITY AND FACTOR VIII-LIKE ANTIGEN: INDEPENDENT MOLECULAR ENTITIESThe Journal of Experimental Medicine, 1973
- Experimental Model for von Willebrand's DiseaseNature, 1973
- The Mode of Action of Antibodies which Destroy Factor VIIIBritish Journal of Haematology, 1972
- Cross-reacting material in congenital factor VIII deficiencies (Haemophilia A and von Willebrand's disease)Thrombosis Research, 1972
- Two Types of Haemophilia (A+ and A−): A Study of 48 CasesBritish Journal of Haematology, 1969
- Spontaneous Inhibitors of Factor VIIIBritish Journal of Haematology, 1968
- Platelet aggregation: Part I Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesivenessJournal of Clinical Pathology, 1962
- A Method for the Study of Antihaemophilic Globulin Inhibitors with Reference to Six CasesBritish Journal of Haematology, 1959