Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
Open Access
- 17 January 2000
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 191 (2), 381-386
- https://doi.org/10.1084/jem.191.2.381
Abstract
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-κB activation via CD40.Keywords
This publication has 39 references indexed in Scilit:
- Normal CD40-mediated activation of monocytes and dendritic cells from patients with hyper-IgM syndrome due to a CD40 pathway defect in B cellsEuropean Journal of Immunology, 1998
- The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid TissuesImmunity, 1998
- Signal transduction through NF-κBImmunology Today, 1998
- Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic RegionPublished by Elsevier ,1996
- Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responsesEuropean Journal of Immunology, 1995
- Mice deficient for the CD40 ligandImmunity, 1994
- A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptorCell, 1994
- CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein.The Journal of Experimental Medicine, 1994
- Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in LymphotoxinScience, 1994
- The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndromeCell, 1993