COMPARATIVE STUDY OF THE CLINICAL EFFECTS OF TOFIZOPAM, NITRAZEPAM AND PLACEBO AS ORAL PREMEDICATION

Abstract

In a double-blind randomized study 47 patients received tofizopam 100 mg orally the night before operation, and 100 mg on the morning of operation; 49 patients received nitrazepam 5 mg and 50 patientS received placebo. On average the nitrazepam group slept better and were better sedated than the tofizopam or placebo groups. Compared with placebo or nitrazepam, tofizopam decreased the excitement of the patients. The effect of tofizopam on apprehension and excitement was ugnificantly better than those of placebo or nitrazepam. Nitrazepam, but not tofizopam, significantly decreased the induction requirements of thiopentone.