Prevention of chromosomal breakage in Fanconi's anemia by cocultivation with normal cells
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 56 (2), 169-171
- https://doi.org/10.1007/bf00295689
Abstract
The frequency of aberration in cultured lymphocytes from patients with Fanconi's anemia was significantly reduced when the cells were cocultivated with normal human lymphocytes. The results suggest that most of the chromosomal aberrations observed in cultured cells from Fanconi patients arise during cultivation and that the presence of normal cells prevents chromosomal damage by means of a hitherto unknown mechanism.Keywords
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