The Effect of Oral Sucrose on Exercise Tolerance in Patients with McArdle's Disease
- 25 December 2003
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 349 (26), 2503-2509
- https://doi.org/10.1056/nejmoa031836
Abstract
Energy metabolism in muscles relies predominantly on the breakdown of glycogen early in exercise. In patients with McArdle's disease, blocked glycogenolysis in muscles results in low exercise tolerance and can lead to muscle injury, particularly in the first minutes of exercise. We hypothesized that ingesting sucrose before exercise would increase the availability of glucose and would therefore improve exercise tolerance in patients with McArdle's disease.Keywords
This publication has 32 references indexed in Scilit:
- Improved energy kinetics following high protein diet in McArdle's syndrome. A 31P magnetic resonance spectroscopy studyActa Neurologica Scandinavica, 2009
- A nonischemic forearm exercise test for McArdle diseaseAnnals of Neurology, 2002
- The exercise metaboreflex is maintained in the absence of muscle acidosis: insights from muscle microdialysis in humans with McArdle's diseaseThe Journal of Physiology, 2001
- Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies.Journal of Clinical Investigation, 1998
- A double blind, placebo controlled, crossover trial of d-ribose in McArdle's diseaseJournal of the Neurological Sciences, 1996
- Metabolism of Branched-Chain Amino Acids and Ammonia During Exercise: Clues from McArdle's Disease*International Journal of Sports Medicine, 1990
- Myopathy in McArdle's SyndromeNew England Journal of Medicine, 1985
- Myophosphorylase deficiency impairs muscle oxidative metabolismAnnals of Neurology, 1985
- High-Resolution Chromosome Sorting and DNA Spot-Blot Analysis Assign McArdle's Syndrome to Chromosome 11Science, 1984
- The Second Wind Phenomenon in McArdle's SyndromeActa Medica Scandinavica, 1967