CHRONIC-ALCOHOLISM AND CANINE EXOCRINE PANCREAS SECRETION - LONG-TERM FOLLOW-UP-STUDY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 72 (2), 238-243
Abstract
Sequential changes in pancreatic secretion were evaluated during a 2-3 yr follow-up study in 8 dogs provided with Thomas gastric and duodenal fistulas. Four animals were given intragastric ethanol (2 g/kg) daily for 3 yr; 4 others served as controls. In alcohol-fed animals, the flow rate and bicarbonate output in response to 1 clinical unit/kg per h of secretin were increased at the end of 2 yr but not after 1 yr of alcohol feeding. At the end of 2 yr, the dose-response curve of pancreatic secretion to cholecystokinin was unchanged but the maximal bicarbonate and water secretion in response to high doses of secretin were increased. These modifications are explained by reduplication of pancreatic ducts secondary to the development of chronic pancreatitis, verified by biopsy. A previous report of an increased cholecystokinin release in the course of chronic alcohol consumption in dogs seems to be attributable to an artefact. The pancreatic response to intraduodenal oleic acid is apparently not significantly modified by 3 yr of alcohol feeding.