Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
Top Cited Papers
- 1 November 2006
- journal article
- research article
- Published by Elsevier in Cancer Cell
- Vol. 10 (5), 375-388
- https://doi.org/10.1016/j.ccr.2006.10.006
Abstract
No abstract availableKeywords
This publication has 58 references indexed in Scilit:
- Bim and Bad mediate imatinib-induced killing of Bcr/Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimeticProceedings of the National Academy of Sciences, 2006
- Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemiaBlood, 2006
- Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on PumaBlood, 2006
- Bcl2's Flexible Loop Domain Regulates p53 Binding and SurvivalMolecular and Cellular Biology, 2006
- Auto-activation of the Apoptosis Protein Bax Increases Mitochondrial Membrane Permeability and Is Inhibited by Bcl-2Published by Elsevier ,2006
- Bcl2 phosphorylation and active PKC α are associated with poor survival in AMLLeukemia, 2006
- Killing cancer cells by flipping the Bcl-2/Bax switchCancer Cell, 2005
- Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesisBiochemical Journal, 2001
- Movement of Bax from the Cytosol to Mitochondria during ApoptosisThe Journal of cell biology, 1997
- Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell deathCell, 1993