ARTERIO-VENOUS DISTRIBUTION OF BRILLIANT VITAL RED AND T-1824 INJECTED INTO DOGS

Abstract

Time-concn. curves of dye in plasma, made by simultaneously sampling arterial and venous blood after the injn. of Brilliant Vital Red and T-1824, show that these 2 dyes may be considered equivalent for this use. The typical courses of such curves in arterial and in femoral, jugular, and hepatic venous bloods before and after hemorrhage are described. These curves explain the difficulties and limitations of the dye-injn. method for fluid bookkeeping in acute hemorrhage expts. The data offer strong opposition to the hypothesis that dye is initially lost from the blood stream at a disproportionate rate. Consistent findings of higher relative cell volumes and plasma protein levels in venous blood than in simultaneous arterial samples are ascribed to the A-V shift of water from plasma to cells.