Mathematical Considerations in the Estimation of Peak Drug Concentrations Under Uniform and Nonuniform Dosing Conditions

Abstract

General 1-compartment model equations for computing peak drug concentrations following uniform and nonuniform dosing are discussed. Evidence is presented to confirm that time of peak concentration times (tmax) following oral or i.m. dosing may be highly variable when doses, dosing intervals or drug elimination rates are changing. A new tmax equation (t.DELTA.max) is presented which can provide correct times for peak concentrations under both fixed and variable dosing and can be used when other tmax equations apply. Clinical examples involving its application are shown using human subjects.