Ethanol Alters Kinetic Characteristics and Function of Striatal Morphine Receptors
- 1 August 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 37 (2), 518-521
- https://doi.org/10.1111/j.1471-4159.1981.tb00487.x
Abstract
Morphine promoted dopamine (DA) synthesis and release in mouse striatum, but mice rendered tolerant and dependent on ethanol were less responsive to morphine''s effects on striatal DA metabolism than control animals. Ethanol feeding produced a change in the affinity of striatal opiate receptors for [3H]dihydromorphine and these ethanol-induced receptor changes may be responsible for the altered biological effect of morphine.Keywords
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