Acute displacement of the diastolic pressure-volume curve of the left ventricle: role of the pericardium and the right ventricle.

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Abstract
The diastolic properties of the diseased canine left ventricle are studied in relationship to the pericardium and the right ventricle with human applications. Shifts of the diastolic curve are attributed to increased intrapericardial pressure or alteration of size or functions of the right ventricle. Pharmacologic and hemodynamic influences of angiotensin, nitroprusside, nitroglycerin and amyl nitrate are explored utilizing these 2 biophysical parameters. The effect of acute ischemia on left ventricular disastolic volume vs. left ventricular pressure is described.