The Action of Norepinephrine, Epinephrine and Isopropyl Norepinephrine on the Rhythmic Function of the Heart
- 1 August 1952
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 6 (2), 238-244
- https://doi.org/10.1161/01.cir.6.2.238
Abstract
The actions of norepinephrine and isopropyl norepinephrine on the rhythmic property of the heart were studied and compared with that of epinephrine. Norepinephrine does not abolish cardiac standstill by carotid sinus stimulation, has no effect on the ventricular rate of heart block and induces a sinus bradycardia. Isopropyl norepinephrine acts similarly to epinephrine in that it abolishes the induced cardiac standstill, increases the ventricular rate of heart block and produces a sinus tachycardia. In the treatment of cardiac arrest, the isopropyl compound appears to possess optimum features as it is very potent in the prevention of cardiac standstill and does not predispose to ventricular fibrillation.Keywords
This publication has 7 references indexed in Scilit:
- THE INFLUENCE OF DRUGS ON THE IRRITABILITY AND AUTOMATICITY OF HEART MUSCLE1950
- Evidence for the Occurrence of Nor-Epinephrine in the Adrenal MedullaScience, 1949
- Effect of 1-(3,4, dihydroxyphenyl)-2-Isopropylaminoethanol, (Isopropylepinephrine) on the Rhythmic Property of the Human Heart.Experimental Biology and Medicine, 1949
- A Specific Sympathomimetic Ergone in Adrenergic Nerve Fibres (Sympathin) and its Relations to Adrenaline and Nor‐AdrenalineActa Physiologica Scandinavica, 1946
- THE ACTION OF PARAHYDROXYPHENYLISOPROPYLAMINE (PAREDRINE) ON THE HEART; A CLINICAL STUDY OF A NEW EPINEPHRINE-LIKE COMPOUNDAnnals of Internal Medicine, 1939
- FURTHER OBSERVATIONS ON THE EFFECT OF DRUGS ON INDUCED CARDIAC STANDSTILLArchives of Internal Medicine, 1934
- TRANSIENT VENTRICULAR FIBRILLATIONArchives of Internal Medicine, 1932