LACK OF CARCINOGENICITY OF 4-HYDROXYBENZO(A)PYRENE,5-HYDROXYBENZO(A)PYRENE,6-HYDROXYBENZOA(A) PYRENE, 7-HYDROXYBENZO(A)PYRENE, 8-HYDROXYBENZO(A)PYRENE, 9-HYDROXYBENZO(A)PYRENE, AND 10-HYDROXYBENZO(A)PYRENE ON MOUSE SKIN
- 1 January 1976
- journal article
- research article
- Vol. 36 (10), 3625-3628
Abstract
Seven phenols of benzo(a)pyrene (4-, 5-, 6-, 7-, 8-, 9-, and 10-hydroxybenzo(a)pyrene) were tested for carcinogenicity on mouse skin by application of 0.4 .mu.mol of compound once every 2 wk for 56 wk. None of the 7 phenols tested was carcinogenic to mouse skin, while treatment with the same dose of benzo(a)pyrene produced tumors in 92% of the treated animals. The lack of carcinogenicity of 7- and 8-hydroxybenzo(a)pyrene indicates that the strong carcinogenic activity previously reported for benzo(a)pyrene-7,8-oxide was not due to either phenolic isomerization product of this arene oxide.This publication has 6 references indexed in Scilit:
- Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.Journal of Biological Chemistry, 1976
- Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.Proceedings of the National Academy of Sciences, 1976
- MUTAGENICITY AND CYTOTOXICITY OF BENZO(A)PYRENE BENZO-RING EPOXIDES1976
- MUTAGENICITY AND CYTOTOXICITY OF BENZO(A)PYRENE ARENE OXIDES, PHENOLS, QUINONES, AND DIHYDRODIOLS IN BACTERIAL AND MAMMALIAN-CELLS1976
- Substrate-Induced Synthesis And Other Properties Of Benzpyrene Hydroxylase In Rat LiverJournal of Biological Chemistry, 1957
- The production of cancer by pure hydrocarbons. VProceedings of the Royal Society of London. B. Biological Sciences, 1940