PROLONGED TURNOVER RATE OF HYDROCORTISONE IN THE NEWBORN INFANT*
- 1 October 1958
- journal article
- letter
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 18 (10), 1127-1131
- https://doi.org/10.1210/jcem-18-10-1127
Abstract
Nine human infants showed a slow disappearance of hydrocortisone after the intravenous administration of 25 mg -half-life of 250 - 2185 minutes, average 977. Infants aged 3-9 days showed a half life of 175 minutes. Children between the ages of 1-12 years had values averaging 96 and adults 112 minutes. The slow disappearance in early infancy was not attributable to a lack of glucuronic-acid transferase, since Tetrahydro-E in two infants aged one day had a half-life of 34-48 minutes.Keywords
This publication has 7 references indexed in Scilit:
- STUDIES ON OESTROGEN METABOLISM IN NEW-BORN BOYSActa Endocrinologica, 1957
- METABOLISM OF FREE AND CONJUGATED 17-HYDROXYCORTICOSTEROIDS IN NORMAL SUBJECTS*Journal of Clinical Endocrinology & Metabolism, 1957
- Physiological Disposition of 4-C14-Cortisol During Late Pregnancy1Journal of Clinical Investigation, 1957
- Effect of Ethinyl Estradiol on Plasma 17-Hydroxycorticosteroids, ACTH Responsiveness and Hydrocortisone Clearance in Man.Experimental Biology and Medicine, 1957
- ADRENOCORTICAL FUNCTION IN ANXIOUS HUMAN SUBJECTS: THE DISAPPEARANCE OF HYDROCORTISONE FROM PLASMA AND ITS METABOLIC FATE*Journal of Clinical Endocrinology & Metabolism, 1957
- New solvent systems for the resolution of corticosteroids by paper chromatographyArchives of Biochemistry and Biophysics, 1955
- THE INVIVO HALF-LIFE OF EXOGENOUS HYDROCORTISONE IN PATIENTS WITH RHEUMATIC FEVER1955