Mydriatic Half-Life of a New Anticholinergic as Affected by Dose, Route, Quaternization.

Abstract

The half-life in mice of the tertiary ammonium drug was independent of dose and route. That of the quaternary was dependent upon log dose and route, possibly as a result of decreased rates of penetration of membrane barriers by the charged ion. The drugs were 9-methyl-3-oxo-9-azabicyclo-(3,3,l)-nonan-7-yl-benzilate maleate and the methobromide quaternary derivative.