The molecular basis for tropomyosin isoform diversity
- 1 September 1991
- Vol. 13 (9), 429-437
- https://doi.org/10.1002/bies.950130902
Abstract
The tropomyosins are a family of actin filament binding proteins. In multicellular animals, they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its possible significance to cellular function.Keywords
This publication has 49 references indexed in Scilit:
- Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4Journal of Molecular Biology, 1990
- Generation of skeletal, smooth and low molecular weight non-muscle tropomyosin isoforms from the chicken tropomyosin 1 geneJournal of Molecular Biology, 1990
- Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeletonCell, 1989
- Coordinate induction of fibronectin, fibronectin receptor, tropomyosin, and actin genes in serum-stimulated fibroblastsExperimental Cell Research, 1989
- Organization of the hTMnm geneJournal of Molecular Biology, 1988
- Characterization of a cDNA defining a gene family encoding TM30pl, a human fibroblast tropomyosinJournal of Molecular Biology, 1987
- An insertion within a variably spliced Drosophila tropomyosin gene blocks accumulation of only one encoded isoformCell, 1985
- Amino acid sequence of equine platelet tropomyosinFEBS Letters, 1983
- Distinct α‐Tropomyosin mRNA Sequences in Chicken Skeletal MuscleEuropean Journal of Biochemistry, 1982
- Structural interpretation of the two-site binding of troponin on the muscle thin filamentJournal of Molecular Biology, 1981