A Comparison of Alkylhydrazines and Their B6-Hydrazones as Convulsant Agents.

Abstract

A comparative study was made of the toxicity in mice of 1,1-dimethyl-hydrazine (UDMH), monomethylhydrazine (MMH) and their respective pyridoxal and pyridcocal-5-phosphate hydrazones. Quantitative data were obtained by measuring time lapse between administration of unbuf-fered saline solution or suspension of the agents and time of onset of first convulsion, and death of animal. The LD50 (10 day) was also estimated for the 6 compounds. The hydrazones were more toxic than the hydrazines; MMH was about 10 times more toxic than UDMH.