PLASMA RENIN IN CONGESTIVE HEART FAILURE IN MAN
- 1 January 1970
- journal article
- research article
- Published by AMPCo in The Medical Journal of Australia
- Vol. 1 (5), 215-217
- https://doi.org/10.5694/j.1326-5377.1970.tb77814.x
Abstract
Conflicting reports of changes in renin activity and angiotensin in congestive heart failure, together with the recent suggestion that the hyperaldosteronism observed is a result of therapy, prompted a reevaluation of the renin‐angiotensin system in this condition. Plasma renin activity in seven patients before therapy was in the normal range for upright subjects receiving a liberal sodium Intake. Of six patients for whom renin activity was determined serially during treatment, five showed a marked rise from a pretreatment mean level of 432 ng/100 ml in three hours to 1,402 ng/100 ml in three hours on the second or third day of treatment. This resembles the normal physiological response of the renin‐anglotensin system to sodium loss. These findings support the suggestion that in heart failure hyperaldosteronism occurs only after treatment is commenced and indicate a possible therapeutic role for aldosterone antagonists in its management.Keywords
This publication has 17 references indexed in Scilit:
- A Pressor Agent in Human Stable Plasma Protein SolutionsCirculation Research, 1968
- Changes in fluid compartments, renal hemodynamics, plasma renin and aldosterone secretion induced by low sodium intakeMetabolism, 1968
- Improved Assay Methods for Renin "Concentration" and "Activity" in Human PlasmaCirculation Research, 1967
- A diurnal rhythm in plasma renin activity in man.JCI Insight, 1966
- Renin and angiotensin. A survey of some aspectsPostgraduate Medical Journal, 1966
- Plasma Renin Concentration in Human Hypertension--III: Renin in Relation to Complications of HypertensionBMJ, 1966
- Aldosterone and the Edema of Congestive Heart FailureArchives of Internal Medicine, 1964
- INFLUENCE OF SODIUM LOADING AND SODIUM DEPLETION ON PLASMA-RENIN IN MANThe Lancet, 1963
- HYPERALDOSTERONISM IN HEART-DISEASEThe Lancet, 1957
- EDEMA AND DECREASED RENAL BLOOD FLOW IN PATIENTS WITH CHRONIC CONGESTIVE HEART FAILURE: EVIDENCE OF “FORWARD FAILURE” AS THE PRIMARY CAUSE OF EDEMA 1JCI Insight, 1946