MEMBRANE-TRANSPORT OF TC-99M-LABELED RADIOPHARMACEUTICALS .1. BRAIN UPTAKE BY PASSIVE TRANSPORT
- 1 January 1979
- journal article
- research article
- Vol. 20 (11), 1181-1188
Abstract
The membrane transport properties of 12 99mTc complexes were studied by determining each complex''s brain uptake index (BUI), extent of protein binding, and octanol-to-saline partition coefficient. The chelating agents used were classified as either N-substituted carbamoylmethyliminodiacetates, substituted oxines, N,N''-diesters of EDTA, or N-substituted derivatives of DTPA [diethylenetriamine-pentaacetic acid]. The 99mTc complexes crossed the blood-brain barrier in proportion to their lipophilicity. Of the 4 types of chelating agents tested, substituted oxines appear to be most suitable for the development of diffusible 99mTc-labeled compounds for imaging nonexcretory organs.This publication has 12 references indexed in Scilit:
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