Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice.
Open Access
- 1 February 1987
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 383 (1), 285-299
- https://doi.org/10.1113/jphysiol.1987.sp016409
Abstract
1. Neuropeptide tyrosine (neuropeptide Y, NPY), a recently isolated endogenous brain peptide, reduces the extracellular population spike evoked by stimulation of stratum radiatum in area CA1 of the in vitro rat hippocampal slice, without reducing the antidromically evoked population spike. To test the hypothesis that NPY acts presynaptically, intracellular recordings were made of pyramidal neurones of area CA1 in vitro. 2. Bath application of 10(‐6) M‐NPY causes a long‐lasting (1‐1.5 h), reversible reduction of the orthodromically evoked excitatory post‐synaptic potential (e.p.s.p.) recorded intracellularly from CA1 pyramidal neurones. This effect on the e.p.s.p. was dependent upon the concentration of NPY. 3. The resting membrane potential, slope input resistance, and action potential threshold, amplitude and duration of the CA1 pyramidal neurones were not affected by NPY. 4. The responses of CA1 pyramidal neurones to ionophoretic pulses of glutamate, applied to the dendrites during synaptic blockade, was also unaffected by NPY. 5. The evidence supports the hypothesis that NPY acts presynaptically in the CA1 region of hippocampus to reduce excitatory input to the pyramidal neurones.This publication has 37 references indexed in Scilit:
- Cardiovascular effects of neuropeptide Y in the nucleus tractus solitarius of rats: Relationship with noradrenaline and vasopressinPeptides, 1985
- Coexistence of neuropeptide Y and somatostatin in rat and human cortical and rat hypothalamic neuronsNeuroscience Letters, 1984
- Norepinephrine-like effects of neuropeptide Y on LH release in the ratLife Sciences, 1984
- High concentrations of a novel peptide, neuropeptide Y, in the innervation of mouse and rat heart.Journal of Histochemistry & Cytochemistry, 1984
- Neuropeptide Y (NPY) depresses the secretion of 3H‐noradrenaline and the contractile response evoked by field stimulation, in rat vas deferensActa Physiologica Scandinavica, 1984
- High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including manNeuroscience Letters, 1983
- Neuropeptide Y: Cerebrovascular innervation an vasomotor effects in the catNeuroscience Letters, 1983
- Neuropeptide Y Distribution in the Rat BrainScience, 1983
- Central administration of neuropeptide Y induces hypotension bradypnea and EEG synchronization in the rat*Acta Physiologica Scandinavica, 1983
- The effects of pancreatic polypeptides and neuropeptide Y on the rat vas deferensPeptides, 1983