Renal Hemodynamic Effects of Adrenaline and "Isuprel": Potentiation of Effects of Both Drugs by Tetraethylammonium

Abstract

The increased pressor responsiveness to adrenalin caused by injn. of tetraethylammonium is shown to be associated with an increase in renal vasoconstriction. The depressor response to injn. of "Isuprel," the N-isopropyl homologue of adrenalin, is shown to be associated with renal vasodilation. The depressor, cardio-accelerator and renal vasodilator effects of "Isuprel" are augmented by prior injn. of tetraethylammonium. On the assumption that the effects of tetraethylammonium are due to blocking of autonomic ganglia, the inhibition of these ganglia increases vascular responsiveness to typical vasoconstrictor and vasodilator sympatheticomimetics.