The vestibular depressant activity of flunarizine and cinnarizine were analyzed as compared to a placebo, in 58 patients with peripheral labyrinthine disorders. The activity of the medications was judged by the reduction of the average velocity of the slow phase of the post-caloric nystagmus, before and after treatment. In spite of being administered in a smaller dose, flunarizine appeared to have a more intense vestibular supressant activity, as judged by different statistical tests.