Insulin Receptor Phosphorylation May Not Be a Prerequisite for Acute Insulin Action
- 23 March 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 223 (4642), 1301-1304
- https://doi.org/10.1126/science.6367041
Abstract
An antiserum to the insulin receptor mimicked insulins acute actions on glucose transport, phosphorylation of integral membrane proteins, and internalization of the insulin receptor in isolated rat adipose cells. These insulinomimetic actions of the antiserum occurred without the equivalent increase in phosphorylation of the .beta. subunit of the insulin receptor observed with insulin. A role of receptor phosphorylation in acute insulin action is now questioned.This publication has 16 references indexed in Scilit:
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