Frozen Phases of Random Heteropolymers in Disordered Media
- 11 March 1996
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 76 (11), 1844-1847
- https://doi.org/10.1103/PhysRevLett.76.1844
Abstract
We consider the behavior of random heteropolymers (RHP's) in random media via Monte Carlo simulations. When the bare heteropolymer prefers unlike segments to be adjacent to each other, the disordered medium induces rather unusual behavior. As temperature is scanned, we find two frozen phases with different “folding” patterns separated by a reentrant phase. The phenomena revealed by our results are elucidated on physical grounds, experimental tests are suggested, and the agreement between the simulation results and a simple analytical calculation is discussed.Keywords
This publication has 23 references indexed in Scilit:
- Adsorption of a polyampholyte chainJournal de Physique II, 1994
- How does a protein fold?Nature, 1994
- Biomolecules: Where the Physics of Complexity and Simplicity MeetPhysics Today, 1994
- The Protein Folding ProblemPhysics Today, 1993
- Protein tertiary structure recognition using optimized Hamiltonians with local interactions.Proceedings of the National Academy of Sciences, 1992
- Random self-interacting chains: a mechanism for protein foldingJournal of Physics A: General Physics, 1991
- Thermodynamics of random copolymer meltsPhysical Review Letters, 1991
- Implications of thermodynamics of protein folding for evolution of primary sequencesNature, 1990
- Mean-Field Model for Protein FoldingEurophysics Letters, 1988
- Spin glasses and the statistical mechanics of protein folding.Proceedings of the National Academy of Sciences, 1987