A New Non-Thrombogenic Surface Prepared by Selective Covalent Binding of Heparin Via a Modified Reducing Terminal Residue
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Medical Devices, and Artificial Organs
- Vol. 11 (2-3), 161-173
- https://doi.org/10.3109/10731198309118804
Abstract
A new method for the covalent binding of heparin to artificial surfaces has been developed. The heparinized surface releases insignificant amounts of heparin and can be regarded as stable. The blood contact properties as studied in vitro revealed that the surface was highly thromboresistant in terms of reduced platelet adhesion, surface catalyzed adsorption and inhibition of thrombin and capacity to prevent clotting of nonanticoagulated blood.This publication has 10 references indexed in Scilit:
- ESCA studies of sulfated polyethylene surfaces modified by adsorption of polyethyleneimine and colloidal silica particlesJournal of Colloid and Interface Science, 1982
- Uptake and inhibition of thrombin by the vascular wallThrombosis Research, 1982
- CONTINUOUS INTRA-ARTERIAL PO2 MONITORING WITH A SURFACE HEPARINIZED CATHETER ELECTRODE - A STUDY OF CONFORMITY IN CONVENTIONAL BLOOD-GAS ANALYSIS AND OF LONG-TERM ELECTRODE FUNCTION IN THE NON-HEPARINIZED DOG1982
- Further characterization of the antithrombin-binding sequence in heparinCarbohydrate Research, 1982
- Uptake and inactivation of thrombin by the fresh, glutardialdehyde or heparin treated human umbilical cord vein endotheliumThrombosis Research, 1981
- Inhibition of thrombin on surfaces coated with immobilized heparin and heparin-like polysaccharides: A crucial non-thrombogenic principleThrombosis Research, 1980
- Platelet and plasma coagulation compatibility of heparinized and sulphated surfacesThrombosis Research, 1979
- Determination of platelet adhesion to polyethylene and heparinized surfaces with the aid of bioluminescence and 51chromium labelled plateletsThrombosis Research, 1977
- Deamination of Carbohydrate Amines and Related CompoundsPublished by Elsevier ,1975
- Cyanohydridoborate anion as a selective reducing agentJournal of the American Chemical Society, 1971