HEMOGLOBIN RADIOACTIVE IRON LIBERATED BY ERYTHROCYTE DESTRUCTION (ACETYLPHENYLHYDRAZINE) PROMPTLY REUTILIZED TO FORM NEW HEMOGLOBIN

Abstract

The Fe liberated from Hb derived from red cells destroyed by acetyl-phenylhydrazine (pyrodin) is utilized readily and nearly quantitatively for the regeneration of Hb in the new red cells during the period of spontaneous recovery from anemia under the conditions of these expts. Also during expts. with normal dogs, where ample reserve Fe stores are available, the Hb Fe of new red blood cells is derived from the Fe of old cells broken down in normal wear and tear of the animal blood, rather than from reserve stores.