Steroid hormone alteration of herpes simplex virus type 1 replication
- 1 January 1978
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 2 (3), 247-252
- https://doi.org/10.1002/jmv.1890020308
Abstract
The effect of steroid hormones on herpes simplex virus type 1 replication was examined. Virus replication studies revealed that various concentrations of prednisolone, hydrocortisone, dexamethasone, or progesterone could decrease virus yields up to a maximum of 99%. Using isopycnic centrifugation in CsCl to separate viral from cell DNA, it was found that virus‐specific DNA synthesis was decreased by 30 to 100% depending on the hormone and concentration used. Cell‐specific DNA synthesis was also adversely affected, but this did not alter cell viability or plating efficiency.Keywords
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