Synthesis of Pyrryl Aryl Sulfones Targeted at the HIV‐1 Reverse Transcriptase
- 1 January 1995
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 328 (3), 223-229
- https://doi.org/10.1002/ardp.19953280304
Abstract
Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1, 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41 compounds is reported. Some structure-activity relationships are discussed also in comparison with the known NPPS (2-nitrophenyl phenyl sulfone).Keywords
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