PHYLOGENETIC ORIGINS OF ANTIBODY STRUCTURE
Open Access
- 1 November 1966
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 124 (5), 901-913
- https://doi.org/10.1084/jem.124.5.901
Abstract
The anuran amphibian, Rana catesbiana, has been found to possess at least two kinds of immunoglobulins corresponding to γG- and γM-classes. These classes have the same chain structures as those of their counterparts in higher animal species. Light chains of both immunoglobulins had molecular weights of 20,000. Heavy chains of the γM-class had molecular weights of 72,100; those of the γG-class had molecular weights of 53,600. The carbohydrate content of the γG-immunoglobulin was 2.1%, and that of the γM-protein was 10.8%. The amino acid compositions of the immunoglobulins were generally similar to those of mammalian immunoglobulins.Keywords
This publication has 22 references indexed in Scilit:
- Reductive dissociation of chicken gamma-G immunoglobulin in neutral solvents without a dispersing agent.Proceedings of the National Academy of Sciences, 1965
- Antibody production in the common frog, Rana temporariaThe Journal of Pathology and Bacteriology, 1965
- THE ANTIGENIC STRUCTURE OF THE POLYPEPTIDE CHAINS OF HUMAN γ-GLOBULINThe Journal of Experimental Medicine, 1962
- ON STRUCTURAL AND FUNCTIONAL RELATIONS BETWEEN ANTIBODIES AND PROTEINS OF THE GAMMA-SYSTEMProceedings of the National Academy of Sciences, 1962
- STUDIES ON STRUCTURAL UNITS OF THE γ-GLOBULINSThe Journal of Experimental Medicine, 1961
- INTERACTION OF THE RHEUMATOID FACTOR WITH ANTIGEN-ANTIBODY COMPLEXES AND AGGREGATED GAMMA GLOBULINThe Journal of Experimental Medicine, 1958
- Dissociation of Human Serum MacroglobulinsScience, 1957
- THE CARBOHYDRATE OF γ-GLOBULIN AND MYELOMA PROTEINSThe Journal of Experimental Medicine, 1956
- Zone ElectrophoresisPublished by Wiley ,1954
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951