DISTRIBUTION OF IGA-1 AND IGA-2 PLASMA-CELLS IN VARIOUS NORMAL HUMAN TISSUES AND IN JEJUNUM OF PLASMA IGA-DEFICIENT PATIENTS
- 1 January 1978
- journal article
- research article
- Vol. 33 (2), 327-331
Abstract
The distribution of Ig[immunoglobulin]A 1 and IgA 2 plasma cells was studied in normal human tissues. IgA 2 is a minor constituent in peripheral lymph nodes and in serum and bone marrow plasma cells. An increased proportion of IgA 2 plasma cells was observed in gastric and intestinal mucosa, bronchial mucosa, salivary and mammary glands. Tonsils and mesenteric lymph nodes exhibit values intermediate between those of central and peripheral lymphoid systems. In patients with plasma IgA-deficiency, IgA 2 was the predominant intestinal IgA plasma cells. This may explain the frequent association of an asymptomatic condition and plasma IgA deficiency.This publication has 8 references indexed in Scilit:
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