EXPERIMENTAL HYDROCEPHALUS

Abstract

Internal hydrocephalus can be produced experimentally by injecting a foreign substance into the ventricles. In these experiments, aleuronat, a granular, insoluble material, has caused an acute inflammatory reaction, characterized in the first week by an exudate consisting largely of polynuclear leucocytes. Later the picture is one of a chronic process; polynuclear cells are replaced by lymphoid and large mononuclear cells and there is proliferation of the connective tissue in the choroid plexus. Proliferation of the ependyma occurs in the first week but becomes more advanced in the second and third weeks, and there is increase in neuroglia more marked in the long continued experiments.